Yankton Rexall's history begins in 1923 when pharmacists George Paulsen and Leon Farrell opened their pharmacy at 111 West Third Street (presently Fish & Stuff) to serve the healthcare needs of the growing Yankton community. Although the store has moved, remodeled a number of times, and later incorporated, it has always been owned by pharmacists and supported by a dedicated staff of employees. The store has been located in historic downtown Yankton since its inception. The store has held a liquor license since the end of prohibition.

Yankton Rexall has survived the many economic challenges of the last century through the determination, foresight and strong work ethic of its past owners and staff. It is the goal of the present ownership and staff to continue the tradition of providing patients and customers with quality medications and products without sacrificing the hometown customer service. You are always welcome at Yankton Rexall!